Closed-loop, ultraprecise, automated craniotomies

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Closed-loop, ultraprecise, automated craniotomies.

A large array of neuroscientific techniques, including in vivo electrophysiology, two-photon imaging, optogenetics, lesions, and microdialysis, require access to the brain through the skull. Ideally, the necessary craniotomies could be performed in a repeatable and automated fashion, without damaging the underlying brain tissue. Here we report that when drilling through the skull a stereotypica...

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1 Closed-loop, ultraprecise, automated craniotomies 2 3 Authors 4 Nikita Pak, Joshua H. Siegle, Justin P. Kinney, Daniel J. Denman, Timothy J. Blanche, 5 Edward S. Boyden 6 7 1 Media Lab and McGovern Institute, Departments of Biological Engineering and Brain and 8 Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. 9 2 Mechanical Engineering, Massachusetts ...

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ژورنال

عنوان ژورنال: Journal of Neurophysiology

سال: 2015

ISSN: 0022-3077,1522-1598

DOI: 10.1152/jn.01055.2014